Composite grey matter fingerprints for genetic frontotemporal dementia
We propose the use of cortical thickness and volume measurements combined from multiple regions into a composite region of interest for each FTD genetic group to identify the earliest changes and track disease progression. Our quasi-longitudinal design illustrates that these regions continue to evolve throughout the symptomatic stages. Investigating how our selected composites progress and validating these in longitudinal samples will be invaluable for future clinical trials.
Authors
- Giulia Campana
- Nicolas Gensollen (ORCID: https://orcid.org/0000-0001-7199-9753)
- Eve Ferry‐Bolder
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- Matthieu Joulot (ORCID: https://orcid.org/0009-0006-2115-3876)
- Judith S. Rowe
- Simon Ducharme
- Bertoux Maxime
- Raffaella Migliaccio
- Fermin Moreno
- Lucy L. Russell
- Harro Seelaar
- Chris R. Butler
- L Jiskoot
- Matthis Synofzik
- Isabel Santana
- Rik Vandenberghe
- Pietro Tiraboschi
- John Cornelis Van Swieten
- Barbara Borroni
- Isabelle Leber
- Mario Masellis
- Caroline Graff
- Markus Otto
- Robert Laforce
- Daniela Galimberti
- Elizabeth Finger
- Sandro Sorbi
- Alexander Gerhard
- Maria Carmela Tartaglia
- Raquel Sánchez-Valle
- Jonathan Daniel Rohrer
- Johannes Levin
- Alexandre de Mendonca
Institutions
- University of Verona (IT)
- Western University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Karolinska University Hospital (SE)
- University of Lisbon (PT)
- Inserm (FR)
- University of Toronto (CA)
- University of Milan (IT)
- Universität Ulm (DE)
- Université de Lille (FR)
- University of Cambridge (GB)
- Douglas Mental Health University Institute (CA)
- German Center for Neurodegenerative Diseases (DE)
- Erasmus MC (NL)
- Health Sciences Centre (CA)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Centre hospitalier universitaire de Québec (CA)
- Assistance Publique – Hôpitaux de Paris (FR)
- Biogipuzkoa Health Research Institute (ES)
- Occupational Cancer Research Centre (CA)
- Munich Cluster for Systems Neurology (DE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Hospital Clínic de Barcelona (ES)
- Don Carlo Gnocchi Foundation (IT)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Klinikum Arnsberg (DE)
- NIHR Queen Square Dementia Biomedical Research Unit (GB)
- Hertie Institute for Clinical Brain Research (DE)
- Onkologikoa (ES)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Ferrari (Italy) (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Florence (IT)
- University College London (GB)
- Imperial College London (GB)
- University of Duisburg-Essen (DE)
- Martin Luther University Halle-Wittenberg (DE)
- University of Coimbra (PT)
- University of Brescia (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1136/jnnp-2025-337186
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00