BDCA2 plays a central role in the binding, internalization and response of plasmacytoid dendritic cells to vidutolimod
These findings indicate BDCA2 plays a dual role in the immune response to Vidu, with the amount of anti-Qb antibody coating Vidu determining whether interaction of Vidu with BDCA2 results in pDC activation or inhibition. This important mechanistic information could influence the design of the next generation of pDC-targeting immunotherapeutic nanoparticles.
Authors
- Chaobo Yin (ORCID: https://orcid.org/0009-0002-1552-6171)
- Caitlin D. Lemke (ORCID: https://orcid.org/0009-0009-3769-7247)
- Travis D Fischer
- Sue E. Blackwell
- George J. Weiner
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3389/fimmu.2026.1769287
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Holden Comprehensive Cancer Center, University of Iowa
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa