Conjunctival allergic inflammation involving the interleukin-23/T helper type 17 immune axis in an experimental allergic conjunctivitis mouse model
IL-23 induces mixed eosinophilic-neutrophilic inflammation in conjunctival tissue, characterized by enhanced Th2 and weak Th17 responses in a murine model of EAC. These findings suggest a modulatory role of the IL-23/Th17 axis in influencing the severity and phenotype of allergic conjunctival inflammation.
Authors
- Rumi Adachi
- Akiko Tomioka (ORCID: https://orcid.org/0000-0001-9278-193X)
- Noriko Inada
- Satoru Yamagami
- Jun Shoji
Institutions
- Nihon University (JP)
Publication Details
- Journal
- Japanese Journal of Ophthalmology
- Published
- 2026-02-13
- DOI
- https://doi.org/10.1007/s10384-026-01333-4
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00