Evaluating dual calcitonin gene‐related peptide antagonists for chronic migraine prevention

Trialing two preventive CGRP antagonists may be an effective approach for some patients with chronic migraine who have exhausted other preventive treatment options, with some patients in this study experiencing a significant reduction in headache frequency and severity. Prospective studies with larger, more diverse populations should be completed to confirm these findings and investigate any potential stroke risks.

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Publication Details

Journal
Headache The Journal of Head and Face Pain
Published
2026-02-12
DOI
https://doi.org/10.1111/head.70057
Primary Topic
Migraine and Headache Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Evaluating dual calcitonin gene‐related peptide antagonists for chronic migraine prevention

Julie MacDougall, Kara S. Graves, Derek Devine, Jason To et al.
Headache The Journal of Head and Face Pain
Migraine and Headache Studies
article

Evaluating dual calcitonin gene‐related peptide antagonists for chronic migraine prevention

Julie MacDougall, Kara S. Graves, Derek Devine, Jason To, Adam S. Sprouse‐Blum, Hayley Paige, Amanda G. Kennedy
article en

Abstract

Trialing two preventive CGRP antagonists may be an effective approach for some patients with chronic migraine who have exhausted other preventive treatment options, with some patients in this study experiencing a significant reduction in headache frequency and severity. Prospective studies with larger, more diverse populations should be completed to confirm these findings and investigate any potential stroke risks.

Headache The Journal of Head and Face Pain
University of Vermont (US), University of Maine School of Law (US), University of Vermont Medical Center (US), MaineHealth (US)
Good health and well-being
Openalex Percentile: Top 61%
Migraine and Headache Studies
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