ω-3 PUFAs Attenuate Postoperative Ileus by Modulating Macrophage Polarization via the JAK2/STAT3 Signaling Pathway
ω-3 PUFAs alleviate POI by inhibiting the JAK2/STAT3 signaling pathway in macrophages, thereby suppressing their polarization toward the pro-inflammatory M1 phenotype and reducing local intestinal inflammation. These findings indicate that ω-3 PUFAs may be a promising prophylactic or therapeutic agent for POI.
Authors
- Liuchuang Zhang
- Huafeng Pan (ORCID: https://orcid.org/0000-0001-6744-3058)
- Y. Lynn Wang (ORCID: https://orcid.org/0000-0003-0773-1212)
- Yi Chen (ORCID: https://orcid.org/0000-0002-4891-8289)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Xuan Zhao (ORCID: https://orcid.org/0000-0002-5650-0747)
- Jing Yu (ORCID: https://orcid.org/0000-0001-7183-0835)
- Zhiwei Jiang (ORCID: https://orcid.org/0009-0009-8237-5570)
- Yufei Zhang (ORCID: https://orcid.org/0009-0009-3863-204X)
- Tianle Zhang
- Miaomiao Ge
- Gang Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s562643
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00