Development of retrieval-augmented generation–based large language model for drug-induced liver injury using Livertox data

We developed an RAG-LLM integrated with LiverTox for evidence-based DILI management. RAG-LLM systems outperformed non-RAG variants and produced responses without observed hallucinations in this evaluation. Our LiverTox RAG-LLM enables reliable answers to drug hepatotoxicity questions at the point of care.

Authors

Hashem B. El‐Serag (ORCID: https://orcid.org/0000-0001-5964-7579)
Terrence White
George T. Cholankeril (ORCID: https://orcid.org/0000-0001-5335-8426)
Avegail Flores (ORCID: https://orcid.org/0000-0002-1742-0293)
Fasiha Kanwal (ORCID: https://orcid.org/0000-0002-1012-8767)
Gagan Sood
Ashwin Rao

Institutions

Baylor College of Medicine (US)
The University of Texas Health Science Center at Houston (US)

Publication Details

Journal: Hepatology Communications
Published: 2026-02-12
DOI: https://doi.org/10.1097/hc9.0000000000000895
Primary Topic: Drug-Induced Hepatotoxicity and Protection
Type: article
Field-Weighted Citation Impact: 0.00

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article

Development of retrieval-augmented generation–based large language model for drug-induced liver injury using Livertox data

Hashem B. El‐Serag, Terrence White, George T. Cholankeril, Avegail Flores et al.

Feb 12, 2026

Hepatology Communications

Drug-Induced Hepatotoxicity and Protection

article

Development of retrieval-augmented generation–based large language model for drug-induced liver injury using Livertox data

Hashem B. El‐Serag, Terrence White, George T. Cholankeril, Avegail Flores, Fasiha Kanwal, Gagan Sood, Ashwin Rao

February 12, 2026article en

Abstract

We developed an RAG-LLM integrated with LiverTox for evidence-based DILI management. RAG-LLM systems outperformed non-RAG variants and produced responses without observed hallucinations in this evaluation. Our LiverTox RAG-LLM enables reliable answers to drug hepatotoxicity questions at the point of care.

Hepatology CommunicationsVol. 10(3)

Baylor College of Medicine (US), The University of Texas Health Science Center at Houston (US)

Openalex Percentile: Top 58%

Drug-Induced Hepatotoxicity and Protection

DOI Open Access PDF OpenAlex

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