A Novel Role for the Small Molecule Cinnamaldehyde in Protecting Against P. gingivalis–Induced Endothelial Dysfunction in Mice: Involvement of PPARγ/Akt/eNOS and Nrf2/ARE Signaling
<i>Pg</i> infection and HFD act as synergistic metabolic and vascular stressors that accelerate endothelial dysfunction through coordinated disruption of PPARγ/Akt/eNOS and Nrf2 pathways, while CNM provides substantial protective effects.
Authors
- Bhavyasri Gaddam
- Chethan Sampath (ORCID: https://orcid.org/0000-0002-6396-227X)
- Alistair Gray
- Pandu R. Gangula (ORCID: https://orcid.org/0000-0001-7259-570X)
- Sasanka S. Chukkapalli
Institutions
- Meharry Medical College (US)
- Texas A&M University (US)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3390/antiox15020243
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00