Multiple sclerosis-associated EBNA2 variants influence the response to peginterferon beta-1a therapy
Here, we found that infection with MS-associated EBNA2 variants might be involved in the clinical response to peg-IFN therapy. The predictive model developed, which integrates immunological and viral parameters, may help clinicians in a finer selection of first-line therapies tailored to patient profiles, supporting personalized medicine approaches.
Authors
- A. Marrone (ORCID: https://orcid.org/0000-0001-6096-1880)
- Eliana M. Coccia (ORCID: https://orcid.org/0000-0002-1606-2949)
- Fabiana Rizzo (ORCID: https://orcid.org/0000-0001-9748-4571)
- Federica Garziano (ORCID: https://orcid.org/0000-0003-0386-7147)
- Caterina Veroni (ORCID: https://orcid.org/0000-0002-6043-1051)
- Teresa Micillo (ORCID: https://orcid.org/0000-0001-5233-8626)
- Francesco Perna (ORCID: https://orcid.org/0000-0002-2177-1184)
- Paola Valentino
- Gisella Guerrera (ORCID: https://orcid.org/0000-0002-3467-6469)
- Chiara Meloni
- Rosella Mechelli
- Daniela Ricci
- Diego Centonze
- Marco Salvetti
- Martina Severa
- Gianmarco Bellucci
- Antonio Bertolotto
- Silvia Romano
- Maria Chiara Buscarinu
- Luca Battistini
- Fortunata Carbone
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituto Superiore di Sanità (IT)
- San Raffaele University of Rome (IT)
- Istituto Neurologico Mediterraneo (IT)
- Federico II University Hospital (IT)
- Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli (IT)
- IRCCS Ospedale San Raffaele (IT)
- Institute for Experimental Endocrinology and Oncology (IT)
- Ospedale Monaldi (IT)
- Fondazione Santa Lucia (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ospedale San Luigi Gonzaga (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Journal of Autoimmunity
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.jaut.2026.103533
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00