Perineural Invasion in Radical Prostatectomy Specimens and Its Association with Biochemical Recurrence and Survival in Prostate Cancer: A Systematic Review and Meta-analysis
We found that detection of cancer cells around nerves, which is called perineural invasion (PNI), in specimens after surgery to remove the prostate, is linked to a higher chance of worse survival outcomes in prostate cancer. Men with PNI were more likely to experience biochemical recurrence and had worse cancer-specific survival. PNI may help in identifying patients at higher risk after surgery who could benefit from closer follow-up or additional treatment. However, more high-quality studies are needed to confirm its role in guiding long-term care.
Authors
- F. Zattoni
- Patryk Patrzałek (ORCID: https://orcid.org/0009-0000-1369-3633)
- Maciej Kaczorowski (ORCID: https://orcid.org/0000-0002-7787-9952)
- Jakub Karwacki (ORCID: https://orcid.org/0009-0005-4441-1877)
- Bartosz Małkiewicz (ORCID: https://orcid.org/0000-0002-5933-3753)
- Adam Gurwin (ORCID: https://orcid.org/0000-0002-9711-6709)
- T Yanagisawa
- Michael Baboudjian
- Laura Wojdyło
- Karolina Klasen
- Paweł Rajwa
- Agnieszka Hałoń
- Tomasz Szydełko
- Wojciech Krajewski
Institutions
- Jikei University School of Medicine (JP)
- University of Padua (IT)
- Aix-Marseille Université (FR)
- Wroclaw Medical University (PL)
- Comprehensive Cancer Center Vienna (AT)
- Postgraduate School of Molecular Medicine (PL)
- University College London (GB)
- Medical University of Vienna (AT)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1016/j.euros.2026.01.018
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00