Predictive Value of Placental Growth Factor and Soluble FMS-Like Tyrosine Kinase-1 Detection in Early Pregnancy for Gestational Diabetes Mellitus: A Case-Control Study

Wen Wu, Xinli Liu Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, People’s Republic of ChinaCorrespondence: Xinli Liu, Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, No. 139, Tongzipo Road, Changsha, Hunan, 410013, People’s Republic of China, Email [email protected]: Gestational diabetes mellitus (GDM) increases the risk of complications such as gestational hypertension, genital tract infections, preterm birth, and adverse perinatal outcomes including fetal distress and macrosomia. Identifying serum biomarkers in early pregnancy may aid in prevention and improve maternal and fetal outcomes.Aim: To evaluate the predictive value of placental growth factor (PIGF) and soluble FMS-like tyrosine kinase-1 (sFlt-1) for GDM in early pregnancy.Methods: A retrospective case-control study was conducted including 140 pregnant women screened for GDM in early pregnancy. Seventy women diagnosed with GDM formed the observation group, and 70 women with normal glucose levels served as controls. Inclusion criteria were singleton pregnancies with complete laboratory data and delivery follow-up at the same hospital. Primary outcomes were serum PIGF and sFlt-1 levels, and their predictive value for GDM was assessed.Results: Pre-pregnancy BMI, fasting plasma glucose, HbA1c, HOMA-IR, and sFlt-1 levels were significantly higher in the observation group, while PIGF levels were lower. Pre-pregnancy BMI, PIGF, and sFlt-1 were independent predictors of GDM (P < 0.05). The incidence of gestational hypertension, preterm birth, genital tract infection, and macrosomia was higher in the observation group (P < 0.05). PIGF was negatively correlated with HOMA-IR, whereas sFlt-1 showed a positive correlation (P < 0.05). The area under the curve (AUC) for predicting GDM was 0.875 (95% CI: 0.818– 0.932) for PIGF and 0.824 (95% CI: 0.752– 0.897) for sFlt-1.Conclusion: Lower PIGF and higher sFlt-1 levels in early pregnancy may be associated with GDM development and adverse outcomes. These biomarkers demonstrate potential predictive value, but large-scale prospective studies are required to confirm clinical utility.Keywords: gestational diabetes mellitus, placental growth factor, PIGF, soluble FMS-like tyrosine kinase-1, sFlt-1, early pregnancy, predictive value