Complement Inhibition for Acute Neuromyelitis Optica Spectrum Disorder Attacks
This retrospective case series provides Class IV evidence that the C5 complement inhibitors eculizumab or ravulizumab may improve disability in patients with NMOSD when given during or shortly after acute relapse.
Authors
- Tatsuro Misu (ORCID: https://orcid.org/0000-0002-7311-2578)
- Paula Barreras (ORCID: https://orcid.org/0000-0002-3837-7183)
- Julia Nolte (ORCID: https://orcid.org/0000-0002-1392-6553)
- Ryan Kammeyer (ORCID: https://orcid.org/0000-0001-8657-3106)
- Samir Alkabie (ORCID: https://orcid.org/0000-0001-5596-514X)
- Asaff Harel
- Kévin Bigaut (ORCID: https://orcid.org/0000-0002-5176-580X)
- Volker Siffrin (ORCID: https://orcid.org/0000-0002-1532-2868)
- Laurent Kremer (ORCID: https://orcid.org/0000-0002-6604-4458)
- Amanda L. Piquet (ORCID: https://orcid.org/0000-0001-7349-6455)
- Kimihiko Kaneko (ORCID: https://orcid.org/0000-0001-8469-9338)
- J. De Seze
- Fu-Dong Shi
- F. Paul
- Orhan Aktas
- Pedro Ortiz Sánchez
- Mallory Lowe
- Frank Leypoldt
- Philippe Bilodeau
- Takahisa Mikami
- Elias Sotirchos
- Wei Jiang
- Michael Levy
- Haiwen Chen
- Jadyn Zook
- Kazuo Fujihara
- Paulus S. Rommer
- Jeffrey L. Bennett
- Hengri Cong
- Lin-Jie Zhang
- Marius Ringelstein
- Thomas Berger
Institutions
- Cedars-Sinai Medical Center (US)
- Hofstra University (US)
- Johns Hopkins University (US)
- Tohoku University (JP)
- Max Delbrück Center (DE)
- Johns Hopkins Medicine (US)
- Lenox Hill Hospital (US)
- Tianjin Medical University General Hospital (CN)
- Humboldt-Universität zu Berlin (DE)
- Beijing Tian Tan Hospital (CN)
- Massachusetts General Hospital (US)
- Düsseldorf University Hospital (DE)
- National Clinical Research Center for Digestive Diseases (CN)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- University Hospital Schleswig-Holstein (DE)
- Multiple Sclerosis Center of Atlanta (US)
- Heinrich Heine University Düsseldorf (DE)
- University of Colorado Anschutz Medical Campus (US)
- Université de Strasbourg (FR)
- Medical University of Vienna (AT)
- University of Colorado Denver (US)
- University of Lübeck (DE)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1212/nxi.0000000000200548
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 36.00
Funders
- U.S. Department of Defense
- Amgen
- AstraZeneca
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Amicus Therapeutics
- Ministry of Education, Culture, Sports, Science and Technology
- Austrian Science Fund
- Chugai Pharmaceutical
- Canadian Institutes of Health Research