Non-specific Clones Hamper the Reliability of Ig Light Chain Gene Rearrangements in Next-Generation Sequencing-Based Measurable Residual Disease Monitoring in Pediatric B-Cell ALL: A Single-Center Cohort Study
Non-specific clones reduce the reliability of <i>IGK</i> rearrangements for NGS-based MRD monitoring in pediatric B-ALL. Filtering out these clones may enhance accu-racy by reducing false positives.
Authors
- Fenying Zhao (ORCID: https://orcid.org/0000-0001-9164-5952)
- Jingying Zhang (ORCID: https://orcid.org/0000-0002-7971-7180)
- Weiqun Xu
- Haipin Chen (ORCID: https://orcid.org/0009-0006-0795-4474)
- Xiaojun Xu
- Susan Wu
- Yongmin Tang
- Diying Shen
- Juan Liang
- Linyang Fan
- Jing Miao
- Tao Sun
- Hua Song
- Heping Shen
Institutions
- Children's Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Annals of Laboratory Medicine
- Published
- 2026-02-12
- DOI
- https://doi.org/10.3343/alm.2025.0486
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00