Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer
Collectively, our findings identify the functional Pin1/Notch3 axis as an escape strategy from chemotherapy-induced cell death, thus suggesting a novel predictive role of the Pin1/Notch3 axis in the platinum response, which could be useful for implementing frontline treatments for HGSOC patients before recurrence.
Authors
- Laura Di Magno (ORCID: https://orcid.org/0000-0001-9446-8752)
- Claudio Talora (ORCID: https://orcid.org/0000-0002-6973-2184)
- Angelica Mancusi (ORCID: https://orcid.org/0009-0008-0150-9825)
- Carmine Nicoletti (ORCID: https://orcid.org/0000-0001-5896-2040)
- Serena Camerini (ORCID: https://orcid.org/0000-0001-6131-4335)
- Sabrina Zema (ORCID: https://orcid.org/0000-0002-7966-5923)
- Maria Valeria Giuli (ORCID: https://orcid.org/0000-0003-2132-9369)
- Alessandra Monti (ORCID: https://orcid.org/0000-0002-6789-7057)
- Gianluca Canettieri (ORCID: https://orcid.org/0000-0001-6694-2613)
- Giannino Del Sal (ORCID: https://orcid.org/0000-0003-2185-6003)
- Domenico Raimondo (ORCID: https://orcid.org/0000-0002-1780-7295)
- A Pernazza
- Maria Gemma Pignataro (ORCID: https://orcid.org/0000-0001-5493-8772)
- Alberto Macone (ORCID: https://orcid.org/0000-0003-0455-1400)
- Alessandra Rustighi
- Bianca Natiello
- Samuele Di Cristofano (ORCID: https://orcid.org/0000-0002-9618-9391)
- Alessandra Giorgi
- Rr Rr
- Marialuisa Casella
- Federica Tomao
- Nunzianna Doti
- Innocenza Palaia
- Daniel D’Andrea
- Rebecca Reali
- Isabella Screpanti
- Giovanna Peruzzi
- Giulia d’Amati
Institutions
- University of Trieste (IT)
- Istituto Superiore di Sanità (IT)
- Italian Institute of Technology (IT)
- University of Bristol (GB)
- IFOM (IT)
- Bambino Gesù Children's Hospital (IT)
- Center for Nano Science and Technology (IT)
- Institute of Biostructure and Bioimaging (IT)
- Istituto Pasteur (IT)
- Sapienza University of Rome (IT)
- International Centre for Genetic Engineering and Biotechnology (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1186/s13046-026-03658-x
- Primary Topic
- Signaling Pathways in Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00