A geometric deep learning framework for genome-wide prediction of enzyme turnover number

By bridging the gap between sequence, structure, and function, KcatNet establishes a robust foundation for advancing understanding of molecular-level mechanisms and accelerating enzyme engineering efforts.

Authors

Yue Bi (ORCID: https://orcid.org/0009-0001-6220-7475)
Huan Yee Koh (ORCID: https://orcid.org/0000-0002-0488-2616)
Guimin Zhang (ORCID: https://orcid.org/0000-0001-6674-5820)
Lukasz Kurgan
Geoffrey I. Webb
Yumeng Zhang
Xin Cui
Tong Pan
Shantong Hu
Jiangning Song
Xiaoyu Wang

Institutions

The University of Melbourne (AU)
Virginia Commonwealth University (US)
Discovery Institute (US)
Australian Regenerative Medicine Institute (AU)
Monash University (AU)
Beijing University of Chemical Technology (CN)

Publication Details

Journal: Genome biology
Published: 2026-02-11
DOI: https://doi.org/10.1186/s13059-026-03986-3
Primary Topic: Protein Structure and Dynamics
Type: article
Field-Weighted Citation Impact: 0.00

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article

A geometric deep learning framework for genome-wide prediction of enzyme turnover number

Yue Bi, Huan Yee Koh, Guimin Zhang, Lukasz Kurgan et al.

Feb 11, 2026

Genome biology

Protein Structure and Dynamics

article

A geometric deep learning framework for genome-wide prediction of enzyme turnover number

Yue Bi, Huan Yee Koh, Guimin Zhang, Lukasz Kurgan, Geoffrey I. Webb, Yumeng Zhang, Xin Cui, Tong Pan, Shantong Hu, Jiangning Song, Xiaoyu Wang

February 11, 2026article en

Abstract

By bridging the gap between sequence, structure, and function, KcatNet establishes a robust foundation for advancing understanding of molecular-level mechanisms and accelerating enzyme engineering efforts.

Genome biologyVol. 27(1)

The University of Melbourne (AU), Virginia Commonwealth University (US), Discovery Institute (US), Australian Regenerative Medicine Institute (AU), Monash University (AU), Beijing University of Chemical Technology (CN)

Openalex Percentile: Top 59%

Protein Structure and Dynamics

DOI Open Access PDF OpenAlex

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A geometric deep learning framework for genome-wide prediction of enzyme turnover number — Yue Bi, Huan Yee Koh, et al. · Genome biology (2026) | TGRS Research Map | TGRS