Biological mechanisms underlying the inflammatory radicular cyst formation-focus on epithelial proliferation: a systematic review of experimental cell and tissue models
IRC development arises from a transition from homeostatic to pathological signaling, in which pro-inflammatory mediator levels inside the periapical chronic inflammation override regulatory checkpoints.
Authors
- Marggie Grajales (ORCID: https://orcid.org/0009-0006-6176-9077)
- Néstor Ríos-Osorio (ORCID: https://orcid.org/0000-0002-6675-6789)
- Sandra Briñez-Rodríguez (ORCID: https://orcid.org/0009-0002-4791-9113)
- Mario Guerrero-Torres (ORCID: https://orcid.org/0000-0003-3660-4925)
- David Betancur-Calle
- Rafael Fernández-Grisales
- Óscar Mauricio Jiménez-Peña
Institutions
- Universidad Santo Tomás (CO)
- Institución Universitaria Esumer (CO)
- Institución Universitaria Colegios de Colombia (CO)
- Clínica CES (CO)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Restorative Dentistry & Endodontics
- Published
- 2026-02-11
- DOI
- https://doi.org/10.5395/rde.2026.51.e7
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00