Inference on function-valued parameters using a restricted score test

It is often of interest to make inference on an unknown function that is a local parameter of the data-generating mechanism, such as a density or regression function. Such estimands can typically only be estimated at a slower-than-parametric rate in nonparametric and semiparametric models, and performing calibrated inference can be challenging. In many cases, these estimands can be expressed as the minimizer of a population risk functional. Here, we propose a general framework that leverages such representation and provides a nonparametric extension of the score test for inference on an infinite-dimensional risk minimizer. We demonstrate that our framework is applicable in a wide variety of problems. As both analytic and computational examples, we describe how to use our general approach for inference on a mean regression function under (i) nonparametric and (ii) partially additive models, and evaluate the operating characteristics of the resulting procedures via simulations. Assessment of effect heterogeneity, inference on density functions, and conditional independence testing are discussed as additional examples.

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Publication Details

Journal
Journal of the Royal Statistical Society Series B (Statistical Methodology)
Published
2026-01-20
DOI
https://doi.org/10.1093/jrsssb/qkag043
Primary Topic
Statistical Methods and Inference
Type
article
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article

Inference on function-valued parameters using a restricted score test

Marco Carone, Ali Shojaie
Journal of the Royal Statistical Society Series B (Statistical Methodology)
Statistical Methods and Inference
article

Inference on function-valued parameters using a restricted score test

Marco Carone, Ali Shojaie
article en

Abstract

It is often of interest to make inference on an unknown function that is a local parameter of the data-generating mechanism, such as a density or regression function. Such estimands can typically only be estimated at a slower-than-parametric rate in nonparametric and semiparametric models, and performing calibrated inference can be challenging. In many cases, these estimands can be expressed as the minimizer of a population risk functional. Here, we propose a general framework that leverages such representation and provides a nonparametric extension of the score test for inference on an infinite-dimensional risk minimizer. We demonstrate that our framework is applicable in a wide variety of problems. As both analytic and computational examples, we describe how to use our general approach for inference on a mean regression function under (i) nonparametric and (ii) partially additive models, and evaluate the operating characteristics of the resulting procedures via simulations. Assessment of effect heterogeneity, inference on density functions, and conditional independence testing are discussed as additional examples.

Journal of the Royal Statistical Society Series B (Statistical Methodology)
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), Infectious Disease Research Institute (US), University of Washington (US), Fred Hutch Cancer Center (US), Cancer Research And Biostatistics (US)
Openalex Percentile: Top 61%
Statistical Methods and Inference
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Inference on function-valued parameters using a restricted score test — Marco Carone, Ali Shojaie · Journal of the Royal Statistical Society Series B (Statistical Methodology) (2026) | TGRS Research Map | TGRS