Adenoviral Inciting Antigen and Somatic Hypermutation in VITT
The results of our study indicate that VITT occurs when, in persons with immunoglobulin light-chain allele IGLV3-21*02 or *03, a specific somatic hypermutation develops that affects antibodies that recognize a specific epitope on the adenoviral core protein pVII, which results in misdirection of antibody targeting toward PF4. (Funded by Deutsche Forschungsgemeinschaft and others; German Clinical Trials Register number, DRKS00025738; EU Post-Authorization Study Register number, EUPAS45098.).
Authors
- Alexander Troelnikov (ORCID: https://orcid.org/0000-0002-7239-3814)
- Luisa Müller (ORCID: https://orcid.org/0000-0001-7942-3273)
- Tim Chataway (ORCID: https://orcid.org/0000-0003-0254-8099)
- Lena Ulm (ORCID: https://orcid.org/0000-0002-3388-8785)
- James McCluskey (ORCID: https://orcid.org/0000-0002-8597-815X)
- T Thiele
- Bridie Armour (ORCID: https://orcid.org/0000-0001-7613-1638)
- Alex D. Colella (ORCID: https://orcid.org/0000-0002-4111-208X)
- Lars Kaderali (ORCID: https://orcid.org/0000-0002-2359-2294)
- Ana Tzvetkova (ORCID: https://orcid.org/0000-0003-1576-6511)
- Zahn Roland
- Chee Wee Tan
- Sören Franzenburg
- Lucy Rutten
- Uwe Völker
- Tom P. Gordon
- Jing Jing Wang
- Andreas Greinacher
- Sabine Ameling
- Theodore E. Warkentin
- Linda Schönborn
Institutions
- South Australia Pathology (AU)
- The University of Melbourne (AU)
- Flinders University (AU)
- Universitätsmedizin Greifswald (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Peter Doherty Institute (AU)
- Johnson & Johnson (Netherlands) (NL)
- The University of Adelaide (AU)
- McMaster University (CA)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1056/nejmoa2514824
- Citations
- 3
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 106.24