Development and Validation of a Computational Histology Artificial Intelligence–Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer
The histomorphology-based GvF biomarker predicted differential treatment benefit of first-line GvF. This biomarker can guide optimal treatment selection for first-line therapy in advanced PDAC.
Authors
- Shawn Hutchinson (ORCID: https://orcid.org/0000-0002-2435-7114)
- Aatur Dilip Singhi (ORCID: https://orcid.org/0000-0003-3930-7096)
- Natalie Moshayedi (ORCID: https://orcid.org/0000-0003-2458-1164)
- R. Grant
- Barbara T. Grünwald (ORCID: https://orcid.org/0000-0002-7541-5206)
- Viswesh Krishna (ORCID: https://orcid.org/0000-0002-2469-2713)
- Vivek Nimgaonkar
- Brent K. Larson (ORCID: https://orcid.org/0000-0002-8116-1089)
- Marcus Smith Noel (ORCID: https://orcid.org/0000-0002-3658-6950)
- Rashmi Samdani (ORCID: https://orcid.org/0000-0003-4909-7838)
- Lesli Ann Kiedrowski (ORCID: https://orcid.org/0000-0001-5081-2005)
- Katelyn Smith
- Kawther Abdilleh
- Snehal Sonawane (ORCID: https://orcid.org/0000-0003-3384-7702)
- Daniela Bevacqua
- Asit Tarsode
- Grainne M. O'Kane
- Anirudh Joshi
- Eric A. Collisson
- Alejandra Alvarez
- Haochen Zhang
- Sudheer Doss
- Dove Keith (ORCID: https://orcid.org/0000-0001-6104-3264)
- Davendra Sohal
- Trevor J. Royce
- Drew Watson
- Jennifer J. Knox
- Ekin Tiu
- Akshay Neema
- Christos Fountzilas
- Arsen Osipov
- Rosalie C. Sears
- Andrew E. Hendifar
- Waleed M. Abuzeid
- Vrishab Krishna
- Vladimir Kazarov
Institutions
- Cedars-Sinai Medical Center (US)
- Roswell Park Comprehensive Cancer Center (US)
- University Health Network (CA)
- Johns Hopkins University (US)
- Oregon Health & Science University (US)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- Pancreatic Cancer Action Network (US)
- Princess Margaret Cancer Centre (CA)
- University of Illinois Chicago (US)
- Fred Hutch Cancer Center (US)
- St. Vincent's University Hospital (IE)
- Essen University Hospital (DE)
- University of Pittsburgh Medical Center (US)
- Oncology Hematology Care (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Wake Forest University (US)
- University of Cincinnati (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1200/jco-25-02199
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00