Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls
In non-cirrhotic PBC, fatigue shows a predominantly muscular phenotype independent of demographics/occupation and decoupled from conventional disease metrics. Chronotype and daytime alertness appear largely preserved, with age driving modest morningness. Findings support integrating fatigue phenotyping into assessment, prioritizing muscle-targeted interventions, and using carefully selected controls and objective endpoints in future studies.
Authors
- Michele Tanturli (ORCID: https://orcid.org/0000-0002-2642-1706)
- Armando Curto (ORCID: https://orcid.org/0009-0004-3745-5997)
- G. Mengozzi
- Andrea Galli
- Erica Nicola Lynch (ORCID: https://orcid.org/0000-0002-2638-2559)
- Gabriele Dragoni (ORCID: https://orcid.org/0000-0001-5752-5113)
- Tommaso Innocenti (ORCID: https://orcid.org/0000-0002-2154-0490)
- Rocco Gabriele Iamello
- Pietro Rossi
- Tommaso Mello
- Leonardo Dei
Institutions
- University of Florence (IT)
Publication Details
- Journal
- World Journal of Hepatology
- Published
- 2026-02-12
- DOI
- https://doi.org/10.4254/wjh.v18.i2.114206
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00