Chronic Paraventricular OX1R Overexpression Induces Oxidative Stress and Hypertension in Rats
Chronic PVN OX1R overexpression induces oxidative stress, sympathetic overactivity, and increased plasma vasopressin, contributing to hypertension development. Targeting PVN OX1R signaling may provide therapeutic benefit for hypertension.
Authors
- Robert A. Larson (ORCID: https://orcid.org/0000-0003-0808-5611)
- Xinqian Chen (ORCID: https://orcid.org/0000-0002-8558-9250)
- Derrick Simet
- Yingli Li
- Qinghui Chen (ORCID: https://orcid.org/0000-0003-4840-4875)
- Lanrong Bi
- Zhying Shan
- Bojun Chen
- Nasibeh Yousefzadehkharvanagh
- Peiying Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Michigan Technological University (US)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-11
- DOI
- https://doi.org/10.64898/2026.02.09.704927
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00