Circ-104792/miR-133a/Bcl-xL influences the proliferation and function of human trophoblastic and decidual stromal cells involved in recurrent abortion disease

Our findings demonstrate that miR-133a promotes RSA-associated cellular dysfunction by targeting Bcl-xL, while circ-104792 acts as a ceRNA to sponge miR-133a, thereby antagonizing its effects. The miR-133a/circ-104792/Bcl-xL axis represents a potential key regulatory network in RSA, presenting potential novel targets for diagnosis and therapy.

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Publication Details

Journal
Frontiers in Genetics
Published
2026-02-11
DOI
https://doi.org/10.3389/fgene.2026.1707900
Primary Topic
Reproductive System and Pregnancy
Type
article
Field-Weighted Citation Impact
0.00

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article

Circ-104792/miR-133a/Bcl-xL influences the proliferation and function of human trophoblastic and decidual stromal cells involved in recurrent abortion disease

Xiaochun Huang, Hongli Zhu, Wenjuan Ma, Panpan Shi et al.
Frontiers in Genetics
Reproductive System and Pregnancy
article

Circ-104792/miR-133a/Bcl-xL influences the proliferation and function of human trophoblastic and decidual stromal cells involved in recurrent abortion disease

Xiaochun Huang, Hongli Zhu, Wenjuan Ma, Panpan Shi, Yuan Ma, Yang Yang
article en

Abstract

Our findings demonstrate that miR-133a promotes RSA-associated cellular dysfunction by targeting Bcl-xL, while circ-104792 acts as a ceRNA to sponge miR-133a, thereby antagonizing its effects. The miR-133a/circ-104792/Bcl-xL axis represents a potential key regulatory network in RSA, presenting potential novel targets for diagnosis and therapy.

Frontiers in GeneticsVol. 17
The Fourth People's Hospital (CN), Tang Du Hospital (CN)
Yakult Bio-Science Foundation
Good health and well-being
Openalex Percentile: Top 57%
Reproductive System and Pregnancy
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