Circ-104792/miR-133a/Bcl-xL influences the proliferation and function of human trophoblastic and decidual stromal cells involved in recurrent abortion disease
Our findings demonstrate that miR-133a promotes RSA-associated cellular dysfunction by targeting Bcl-xL, while circ-104792 acts as a ceRNA to sponge miR-133a, thereby antagonizing its effects. The miR-133a/circ-104792/Bcl-xL axis represents a potential key regulatory network in RSA, presenting potential novel targets for diagnosis and therapy.
Authors
- Xiaochun Huang
- Hongli Zhu
- Wenjuan Ma
- Panpan Shi
- Yuan Ma
- Yang Yang
Institutions
- The Fourth People's Hospital (CN)
- Tang Du Hospital (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-02-11
- DOI
- https://doi.org/10.3389/fgene.2026.1707900
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yakult Bio-Science Foundation