Evaluation of LCN2 and miR-8078 as diagnostic biomarkers for congenital heart disease-associated pulmonary arterial hypertension
Plasma LCN2 and miR-8078 are significantly elevated in patients with CHD-PAH and correlate positively with hemodynamic severity. LCN2, in particular, serves as a robust independent biomarker for the diagnosis and severity assessment of CHD-PAH. Consequently, LCN2 and miR-8078 hold promise as potential non-invasive biomarkers for the diagnosis and severity assessment of CHD-PAH.
Authors
- R. Stephanie Huang (ORCID: https://orcid.org/0000-0002-9862-0368)
- Xiaofei Li (ORCID: https://orcid.org/0000-0001-7661-0436)
- Qianqian Chen (ORCID: https://orcid.org/0000-0003-4337-4267)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Ying Hua
- Dongdong Zheng
- Wei Wang
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second People's Hospital of NanTong (CN)
Publication Details
- Journal
- ESC Heart Failure
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1093/eschf/xvag034
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00