Protective effect of scorpion‐venom heat‐resistant peptide (SVHRSP) against depression associated with Parkinson's disease via suppression of CREB‐Akt pathway‐mediated inflammation
The results indicate that SVHRSP mitigates motor deficits, depressive symptoms and cognitive impairments in MPTP-induced DPD mice by suppressing CREB-Akt-mediated neuroinflammation and modulating synaptic plasticity. The multitarget mechanism of SVHRSP underscores its potential as a novel therapeutic candidate for DPD.
Authors
- Salman Shaikh (ORCID: https://orcid.org/0000-0001-8905-204X)
- Qi‐Fa Li
- Ao‐Ran Sui (ORCID: https://orcid.org/0009-0006-3205-0944)
- Yifan Zhao (ORCID: https://orcid.org/0000-0001-8986-9164)
- Shao Li (ORCID: https://orcid.org/0000-0002-4889-8636)
- Song‐Yu Guo
- Yu Ai
- Muhammad Khalid Iqbal
- Kabir Ahmad
- Bakhtawar Khan
- Chun‐Li Zhao
- Bin Wang
- Muhammad Ibrahim Khalil
- Yuxuan Ge
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1111/bph.70364
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00