Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis

Identifying autoimmune encephalitis (AIE) in patients with predominant psychiatric symptoms poses a diagnostic challenge for psychiatrists and neurologists, especially when CSF and MRI findings are inconclusive. We report a case of septin-7 AIE presenting as steroid-responsive psychosis, whose definite diagnosis could only be made years after onset.

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Publication Details

Journal
Translational Psychiatry
Published
2026-02-11
DOI
https://doi.org/10.1038/s41398-026-03877-y
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis

Arnim Johannes Gaebler, Irene Neuner, Malte Teußer, Ana Novaković et al.
Translational Psychiatry
Autoimmune Neurological Disorders and Treatments
article

Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis

Arnim Johannes Gaebler, Irene Neuner, Malte Teußer, Ana Novaković, Madeleine Scharf, Christian Boy, Marieluise Kirchner, P Mertins, Yvonne Weber, Friederike A. Arlt, Harald Prüss, Thomas Frodl
article en

Abstract

Identifying autoimmune encephalitis (AIE) in patients with predominant psychiatric symptoms poses a diagnostic challenge for psychiatrists and neurologists, especially when CSF and MRI findings are inconclusive. We report a case of septin-7 AIE presenting as steroid-responsive psychosis, whose definite diagnosis could only be made years after onset.

Translational PsychiatryVol. 16(1)
Forschungszentrum Jülich (DE), Max Delbrück Center (DE), University Medical Center Freiburg (DE), German Center for Neurodegenerative Diseases (DE), Humboldt-Universität zu Berlin (DE), Euroimmun Medizinische Labordiagnostika (Germany) (DE), Brain (Germany) (DE), Universitätsklinikum Aachen (DE), Jülich Aachen Research Alliance (DE), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE), RWTH Aachen University (DE)
Clean water and sanitation
Openalex Percentile: Top 61%
Autoimmune Neurological Disorders and Treatments
DOIOpen Access PDFOpenAlex
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Seeing elephants and drinking water from a porcelain vase - A case of septin-7 antibody-associated encephalitis presenting as a severe disorganized psychosis — Arnim Johannes Gaebler, Irene Neuner, et al. · Translational Psychiatry (2026) | TGRS Research Map | TGRS