A Giant Thoracic <i>ALK</i> ‐Rearranged Mesenchymal Neoplasm in a Child
Our findings indicate that ALK-rearranged mesenchymal neoplasms with fibrosarcoma-like features, particularly those associated with elevated mitotic activity or tumor necrosis, should be classified as high grade in pathology reports. In addition, this case also demonstrated that neoadjuvant therapy may be a better treatment strategy compared to upfront surgery for ALK-rearranged mesenchymal neoplasms with a relatively high tumor burden.
Authors
- Nie Xiu
- Jingyu He (ORCID: https://orcid.org/0000-0003-0370-8867)
- Jun Fan (ORCID: https://orcid.org/0000-0002-1433-7283)
- D J Luo
- Xiaona Chang
- Sheng Gao
- Bo Huang
- Xiaochuan Dong
- Junhua Wu
- Heshui Shi
Institutions
- Wuhan Union Hospital (CN)
Publication Details
- Journal
- Cancer Reports
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cnr2.70489
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- National Key Research and Development Program of China