Primary infliximab failure in pediatric colonic inflammatory bowel disease: Development of a proteomics predictive model using a prospective Canadian cohort
A serum proteomics linear model on treatment-naïve serum best predicted PNR. Findings require external validation but suggest that the diagnostic/pretreatment window may be key to understanding biology central to effective drug sequencing.
Authors
- Mary Zachos (ORCID: https://orcid.org/0000-0002-5582-2760)
- Eytan Wine
- Nicholas Carman
- Andrei L. Turinsky (ORCID: https://orcid.org/0000-0002-5555-8461)
- Sarah Löw (ORCID: https://orcid.org/0000-0001-7587-6435)
- Jennifer deBruyn (ORCID: https://orcid.org/0000-0001-6812-7620)
- Thomas Walters
- S Lawrence
- K Jacobson
- P C Church
- Emma Broer
- Anthony R Otley
- Eric I Benchimol
- Colette Deslandres
- Anne M Griffiths
- David R Mack
- Hien Q Huynh
Institutions
- University College Dublin (IE)
- Dalhousie University (CA)
- University of Alberta (CA)
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- Hospital for Sick Children (CA)
- Alberta Children's Hospital (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- Institute for Clinical Evaluative Sciences (CA)
- Institute for Work & Health (CA)
- BC Children's Hospital (CA)
- McMaster University (CA)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-12-18
- DOI
- https://doi.org/10.1093/ibd/izaf329
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00