Vitamin <scp>D</scp> Modulates Doxorubicin‐Induced <scp>ACE2</scp> Expression and Pro‐Inflammatory Cytokines in the Rat Tongue
DOX administration is associated with increased ACE2 expression in tongue tissue and systemic inflammation in a rat model. Vitamin D supplementation mitigates these DOX-induced alterations; however, within the tested dose range, no additional benefit of the higher vitamin D dose was demonstrated. These findings suggest a potential modulatory role of vitamin D on chemotherapy-associated inflammatory and molecular changes, while highlighting the need for further mechanistic and functional studies.
Authors
- Necla Değer (ORCID: https://orcid.org/0000-0001-7239-3331)
- Aras Erdil (ORCID: https://orcid.org/0000-0002-9582-5114)
- Hatice Aygün (ORCID: https://orcid.org/0000-0002-4272-0562)
- Mustafa Sami Demïrsoy (ORCID: https://orcid.org/0000-0001-8654-2799)
- Sefa ÇOLAK
- Ali Tuğrul Akin
- Derya Karabulut
- Fadime Demir
Institutions
- Sakarya University (TR)
- Usak University (TR)
- Tokat Gaziosmanpaşa Üniversitesi (TR)
- Istinye University (TR)
- Erciyes University (TR)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1111/jop.70127
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00