Within-host evolution of drug tolerance in <i>Mycobacterium tuberculosis</i>
Our findings confirm that antibiotic tolerance evolves in Mtb within patients over time during treatment. However, there was no evidence that this tolerance influences treatment responses, calling for further investigation of contributors to adverse treatment responses and their mitigation.
Authors
- Nino Maghradze (ORCID: https://orcid.org/0000-0003-1227-1900)
- Anna Doetsch
- Sònia Borrell (ORCID: https://orcid.org/0000-0001-6661-6957)
- Galo Adrián Goig (ORCID: https://orcid.org/0000-0002-4136-6610)
- Jugheli Levan
- Miriam Reinhard
- Teona Avaliani (ORCID: https://orcid.org/0000-0001-8587-7650)
- Kakha Mchedlishvili
- Valerie F. A. March (ORCID: https://orcid.org/0009-0007-0044-6466)
- Sevda Kalkan
- Zaza Avaliani
- Rusudan Aspindzelashvili
- Maia Kipiani
- Nestani Tukvadze
- Sebastien Gagneux
- Selim Bouaouina
Institutions
- Tbilisi State University (GE)
- Swiss Tropical and Public Health Institute (CH)
- University of Basel (CH)
- Agricultural University of Georgia (GE)
- National Center for Tuberculosis and Lung Disease (GE)
- University of Georgia (GE)
- David Tvildiani Medical University (GE)
- Free University of Tbilisi (GE)
- EU Business School, Geneva (CH)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/jacamr/dlag007
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00