Label-free morpho-molecular live-cell phenotyping propels biological discovery
Label-free morpho-molecular imaging circumvents the invasiveness of conventional omics while rapidly delivering quantitative phenotypes of live cells and three-dimensional cell aggregates. By integrating phase tomography with spontaneous and coherent Raman spectroscopy, we reveal and track elusive yet critical cell states in developmental and cancer biology.
Authors
- Dario Polli (ORCID: https://orcid.org/0000-0002-6960-5708)
- Arianna Bresci (ORCID: https://orcid.org/0000-0003-3022-8834)
- Renzo Vanna (ORCID: https://orcid.org/0000-0001-6218-8393)
- Jeon Woong Kang
- Peter T. C. So
Institutions
- Istituto di Fotonica e Nanotecnologie (IT)
- Massachusetts Institute of Technology (US)
Publication Details
- Published
- 2026-02-12
- DOI
- https://doi.org/10.1117/12.3098910
- Primary Topic
- Spectroscopy Techniques in Biomedical and Chemical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00