TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice
These data show that TREM2 plays a protective role in CM by modulating microglial activation and autophagy in the TNC via the mTOR/p70s6k pathway.
Authors
- Zhiwen Zeng (ORCID: https://orcid.org/0000-0001-6398-8480)
- Sufang Zhong
- Zhi Liang
- Lang Zhang (ORCID: https://orcid.org/0000-0002-2397-6861)
- Li Yi (ORCID: https://orcid.org/0009-0002-2872-2569)
- Baodong Chen
- Xiamin Liu
- Suifa Hu
- Rikang Wang
- Weixian Zeng
Institutions
- Southern University of Science and Technology (CN)
- Shenzhen KangNing Hospital (CN)
- Second Hospital of Nanchang (CN)
- Peking University Shenzhen Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-02-11
- DOI
- https://doi.org/10.1111/bph.70353
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 30.63