Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split‐Hand, Randomized, Double‐Blind Clinical and In Vitro Study
Both treatments demonstrated comparable clinical outcomes, suggesting that the strong biostimulating effect of CaHA may have overshadowed potential additive effects of PMN. Nonetheless, in vitro findings confirmed enhanced biological activity with CaHA + PMN, supporting its investigation as a complementary strategy in future studies.
Authors
- Ricardo Frota Boggio (ORCID: https://orcid.org/0000-0002-5139-0243)
- Gláucia Maria Machado‐Santelli (ORCID: https://orcid.org/0000-0003-2046-9693)
- Ana Carolina Henriques Ribeiro Machado (ORCID: https://orcid.org/0000-0002-4686-9006)
- Rebecca Ignacio Subirá Medina (ORCID: https://orcid.org/0000-0001-6756-4263)
- Gladstone Eustáquio de Lima Faria (ORCID: https://orcid.org/0000-0002-0754-2019)
- LUCIANA CARMEN ZATTAR
- Beatriz Domenici de Oliveira
- Renata M M Viana
- Agnaldo Castro Filho
- Cibele Hasmann
Institutions
- Universidade de São Paulo (BR)
- Instituto Adolfo Lutz (BR)
- Microsoft (Brazil) (BR)
- Universidade Cidade de São Paulo (BR)
- Hospital Universitário da Universidade de São Paulo (BR)
Publication Details
- Journal
- Journal of Cosmetic Dermatology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/jocd.70716
- Primary Topic
- Facial Rejuvenation and Surgery Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00