Exploring the risk of depression and suicide/self-injury in patients receiving GLP-1RAs combined with metformin versus GLP-1RA monotherapy: a real-word analysis of the FAERS database

The combination of GLP-1RAs and metformin is linked to a higher risk of depression and suicide/self-injury compared with the GLP-1RAs monotherapy.

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Publication Details

Journal
Endocrine Connections
Published
2026-02-01
DOI
https://doi.org/10.1530/ec-25-0403
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring the risk of depression and suicide/self-injury in patients receiving GLP-1RAs combined with metformin versus GLP-1RA monotherapy: a real-word analysis of the FAERS database

Jie Fang, Linwei Chen, Ying Ma, Wenjun Ji
Endocrine Connections
Diabetes Treatment and Management
article

Exploring the risk of depression and suicide/self-injury in patients receiving GLP-1RAs combined with metformin versus GLP-1RA monotherapy: a real-word analysis of the FAERS database

Jie Fang, Linwei Chen, Ying Ma, Wenjun Ji
article en

Abstract

The combination of GLP-1RAs and metformin is linked to a higher risk of depression and suicide/self-injury compared with the GLP-1RAs monotherapy.

Endocrine ConnectionsVol. 15(2)
Shanghai Jiao Tong University (CN), Nantong University (CN), Ruijin Hospital (CN), The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN), Nanjing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 61%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
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