Homocysteine as a biomarker in arthritis and depression: Evidence from NHANES and gene expression studies

This investigation reveals the overlapping genetic signatures that explain the common manifestations and the association between RA and MDD. The two diseases share DEGs of CBS, VNN1, and TXN, which indicates that the abnormal metabolic pathway of homocysteine is a common pathogenic pathway in RA and MDD. NHANES proved an association between Hcy and depression in arthritis participants, indicating that Hcy may be an important biomarker for intervention to delay or ultimately prevent comorbidities, and highlights the importance of dietary interventions such as supplementing folate. The knowledge may help develop novel therapies and a potential strategy to prevent or delay the coexistence of depression and arthritis, especially RA.