TARGETED HEPATIC METHYLATION-CONTROLLED J PROTEIN INHIBITION MITIGATES POST-SURGICAL LIVER INJURY AND NEUROINFLAMMATION IN AGED MICE
Targeted hepatic MCJ inhibition mitigates subclinical liver injury, dysregulated kynurenine metabolism, and subsequent neuroinflammation in aged mice after surgery. This liver-brain axis modulation represents a potential therapeutic strategy to prevent perioperative neurological complications in vulnerable older surgical patients.
Authors
- Travis Walrath (ORCID: https://orcid.org/0000-0002-7236-1388)
- Juan Pablo Palacios Idrovo
- Rachel H. McMahan (ORCID: https://orcid.org/0000-0003-2162-2821)
- Kevin M. Najarro (ORCID: https://orcid.org/0000-0002-4485-533X)
- Elizabeth J. Kovacs (ORCID: https://orcid.org/0000-0002-9459-9928)
- Mercedes Rincón (ORCID: https://orcid.org/0000-0002-6663-2225)
- Kenneth Meza Monge (ORCID: https://orcid.org/0000-0001-5509-5148)
- Akshay Pratap
Institutions
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Shock
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1097/shk.0000000000002684
- Primary Topic
- Enhanced Recovery After Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00