Plasma Exosomal LncRNA XIST Impairs CD4+ T Cell Autophagy and Promotes Activation via the miR-98/RICTOR/Akt-mTOR Axis in Systemic Lupus Erythematosus
Plasma exosomal lncRNA XIST impairs CD4<sup>+</sup> T cell autophagy and promotes activation through the miR-98/RICTOR/Akt-mTOR axis, representing a mechanistically defined candidate biomarker and potential therapeutic target in SLE.
Authors
- Mingyu Chu
- Chenghui Zheng
- Jinhua Xu
- Lin Xie
- Jun Liang
- Xi Chen
- Li Wang
- Fan Lyu
Institutions
- Fudan University (CN)
- Shanghai Institute of Hematology (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jir.s574715
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China