Examining the Clinical Usefulness of Urine Methylmalonic Acid for Diagnosis of Vitamin B-12 Deficiency in Older Adults: A Pilot Study
Urinary methylmalonic acid is a promising biomarker for assessing vitamin B-12 deficiency and treatment response in older adults. Larger, well-designed studies with extended supplementation periods are needed to confirm its clinical utility and better evaluate the impact of prolonged supplementation on balance, cognitive and neurophysiological outcomes.
Authors
- Isabelle Reid
- Nancy Presse (ORCID: https://orcid.org/0000-0002-5831-8666)
- Mohamed Gamrani (ORCID: https://orcid.org/0000-0003-3742-2103)
- Christiane Auray-Blais
- Hassiba Chebbihi
- Charlotte Bédard-Delisle
- Guillaume Leonard
Institutions
- Université de Sherbrooke (CA)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Health and Social Services Centre University Institute of Geriatrics of Sherbrooke (CA)
Publication Details
- Journal
- Clinical Interventions in Aging
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/cia.s542543
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds de Recherche du Québec - Santé