Cycloastragenol Derivatives Improve Tyrosine Metabolism, Regulate <scp>TLR4</scp> / <scp>NF</scp> ‐ <scp>κB</scp> / <scp>TERT</scp> Signaling Pathways, and Inhibit <scp>MPTP</scp> Induced Neuroinflammation and <scp>PD</scp> Symptoms
This study focuses on the potential mechanism of CAG derivative R2 in treating PD through "inflammation-aging" research. By inhibiting inflammation and restoring telomerase activity, it breaks the vicious cycle and provides new ideas for the treatment of PD, laying a foundation for the development of drugs using CAG for PD.
Authors
- Z. Chai
- Lianmei Liu
- Lei Xu
- Shengnan Xiao
- Zhenyu Li
Institutions
- Shanghai Institute of Materia Medica (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70787
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanxi University