Synthesis of N’-(diphenylmethylene)-3-(amino)propanehydrazide Derivatives and Evaluation for Cholinesterase Inhibitor and Antioxidant Activities

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most prevalent form of dementia, affecting millions of individuals worldwide. It is characterized by a gradual decline in cognitive functions, ultimately impairing patients’ ability to perform daily activities. Multiple pathogenic mechanisms have been implicated in AD, including disturbances in the cholinergic system, oxidative stress, metal ion dysregulation, and amyloid-β (Aβ) aggregation.In the present study, four novel N’-(diphenylmethylene)-3-(amino)propanehydrazide derivatives were designed, synthesized, and subsequently evaluated for their cholinesterase inhibitory and antioxidant activities. These compounds may serve as promising starting points for the development of new molecular design strategies targeting AD-related pathways.