AI-assisted interpretation of bone scans: Performance comparison between ChatGPT-4o and a TFDA-approved bone scintigraphy platform in AI-driven nuclear imaging interpretation

ChatGPT-4o showed preliminary potential for detecting bone metastases and assisting in structured report drafting, but its limited lesion-localization performance restricts clinical applicability. The BS platform, developed specifically for bone scintigraphy, demonstrated more consistent regional accuracy in this dataset. These results represent an early proof-of-concept comparison, suggesting feasibility for reporting support rather than clinical deployment. Larger, multi-center studies and domain-specific training will be needed to clarify large language models' future role in nuclear medicine.