Solitary chemosensory cells amplify eosinophilic inflammation via PAR-2 activation in house dust mite-sensitized allergic rhinitis
These findings demonstrated that SCCs could sense HDM and produce IL-25, triggering mucin overproduction and eosinophilic IL-25 receptor expression via PAR-2 activation, which suggesting that SCCs might be powerful immunomodulators of nasal eosinophilic inflammation in HDM-AR.
Authors
- Liyue Li (ORCID: https://orcid.org/0009-0001-9015-8252)
- Jianxin Yue
- Liuqing Zhou
- Han Wu
- Qing Cheng
- Tao Zhou
- Yanyan Ding
- Hongjun Xiao
- Jianjun Chen
- Yue Zhou
- Yan Zou
- Shan Chen
- Pei Gao
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.waojou.2026.101336
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00