Iridium‐Catalyzed C–H Silylation of Indoles With Hydrosilanes in Aqueous Media
ABSTRACT Herein, we report that directed C–H silylation of indoles and a pyrrole derivative with hydrosilanes in aqueous media under air was achieved under iridium catalysis. This reaction enables the introduction of a silyl group at the C2 position of a wide range of indoles. The protocol represents the first example of a transition metal‐catalyzed C–H silylation in aqueous media as a sustainable solvent for C–H functionalization of indoles.
Authors
- Xuyao Zhong
- Xinni Tang
- Jingyi Zhan
- Wenjie Hu
- Lei Yang
Institutions
- Hangzhou Normal University (CN)
Publication Details
- Journal
- Applied Organometallic Chemistry
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1002/aoc.70536
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00