LYSC98 as a novel vancomycin-derived agent effective against antibiotic-resistant pathogens in tolerant state
LYSC98's rapid bactericidal activity, selective disruption of bacteria without harming mammalian cells and low propensity for resistance development make it a novel promising candidate for combating chronic, clinically recalcitrant infections.
Authors
- Jie Chen (ORCID: https://orcid.org/0000-0002-9254-4413)
- Xiuping Qian
- Mei Ge (ORCID: https://orcid.org/0000-0002-3094-8877)
- Xing Xia
- Daijie Chen
- Yu Yin
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Medical Information Center (CN)
- Shanghai Institute of Pharmaceutical Industry (CN)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-21
- DOI
- https://doi.org/10.1093/jac/dkag036
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00