Extraocular Sebaceous Carcinoma of the Toe in a Young Adult

Sebaceous carcinoma is a rare and potentially aggressive malignant adnexal tumour, most commonly occurring in the periocular region. Extraocular presentations, particularly involving the extremities, are uncommon and may pose diagnostic and management challenges due to their non-specific clinical appearance. We report the case of a 22-year-old female who presented with a chronic non-healing lesion over the medial aspect of the right big toe. The lesion had been present for 2 years with progressive enlargement. Initial excision and skin grafting were performed at an outside hospital; however, histopathology revealed positive surgical margins and the wound failed to heal. Further evaluation confirmed sebaceous carcinoma with deep margin involvement. The patient was referred to a tertiary care centre, where definitive wide local re-excision achieved clear margins. The surgical defect healed completely by secondary intention without the need for further reconstruction. This case highlights an unusual presentation of extraocular sebaceous carcinoma in a young patient and underscores the importance of early suspicion, accurate histopathological diagnosis and complete surgical excision with clear margins. Adequate oncologic management can result in favourable outcomes even in rare and atypical presentations.

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Publication Details

Journal
Journal of Advanced Trends in Medical Research
Published
2025-10-01
DOI
https://doi.org/10.4103/atmr.atmr_2_26
Primary Topic
Nonmelanoma Skin Cancer Studies
Type
article
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article

Extraocular Sebaceous Carcinoma of the Toe in a Young Adult

Ezdehar Fallatah, Shahad Faiz Felemban, Thekra Abdulhafith Alwafi, Sultanah Khaild Alamoudi et al.
Journal of Advanced Trends in Medical Research
Nonmelanoma Skin Cancer Studies
article

Extraocular Sebaceous Carcinoma of the Toe in a Young Adult

Ezdehar Fallatah, Shahad Faiz Felemban, Thekra Abdulhafith Alwafi, Sultanah Khaild Alamoudi, Abdulaziz Fahad A Samandar
article en

Abstract

Sebaceous carcinoma is a rare and potentially aggressive malignant adnexal tumour, most commonly occurring in the periocular region. Extraocular presentations, particularly involving the extremities, are uncommon and may pose diagnostic and management challenges due to their non-specific clinical appearance. We report the case of a 22-year-old female who presented with a chronic non-healing lesion over the medial aspect of the right big toe. The lesion had been present for 2 years with progressive enlargement. Initial excision and skin grafting were performed at an outside hospital; however, histopathology revealed positive surgical margins and the wound failed to heal. Further evaluation confirmed sebaceous carcinoma with deep margin involvement. The patient was referred to a tertiary care centre, where definitive wide local re-excision achieved clear margins. The surgical defect healed completely by secondary intention without the need for further reconstruction. This case highlights an unusual presentation of extraocular sebaceous carcinoma in a young patient and underscores the importance of early suspicion, accurate histopathological diagnosis and complete surgical excision with clear margins. Adequate oncologic management can result in favourable outcomes even in rare and atypical presentations.

Journal of Advanced Trends in Medical ResearchVol. 2(4)
Umm al-Qura University (SA), King Fahad Hospital Jeddah (SA)
Good health and well-being, Gender equality
Openalex Percentile: Top 26%
Nonmelanoma Skin Cancer Studies
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Extraocular Sebaceous Carcinoma of the Toe in a Young Adult — Ezdehar Fallatah, Shahad Faiz Felemban, et al. · Journal of Advanced Trends in Medical Research (2025) | TGRS Research Map | TGRS