Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis
Mucosal transcriptomics identifies IL-36 secretion as a feature of life-threatening paediatric RSV and all-cause bronchiolitis associated with interferon response failure.
Authors
- Claudia Efstathiou (ORCID: https://orcid.org/0000-0001-6125-8126)
- Sam Strickson (ORCID: https://orcid.org/0000-0002-9208-2028)
- Fiona J. Culley (ORCID: https://orcid.org/0000-0001-5208-4259)
- Dawid Swieboda
- Simon Nadel
- Xavier Romero-Ros
- Megan V.C. Barnes
- Sophie W.H. Stretch
- Peter J.M. Openshaw
- E. Suzanne Cohen
- Trevor T. Hansel
- Ryan S. Thwaites
Institutions
- AstraZeneca (United Kingdom) (GB)
- Imperial College Healthcare NHS Trust (GB)
- Lung Institute (US)
- NIHR Imperial Biomedical Research Centre (GB)
- St Mary's Hospital (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Mucosal Immunology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.mucimm.2026.01.012
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00