Optimizations of Cas12a‐ and Cas12i‐based adenine base editors for efficient precision editing in the plant genome
A strategy coupling high-activity nucleases with dimeric TadA-8e optimizes plant Cas12-based adenine base editors, boosts editing efficiency, and provides precise editors for crop breeding and genomics research.
Authors
- Xiao Zhi (ORCID: https://orcid.org/0000-0001-6527-7551)
- Dongfang Gu
- Shan Jin (ORCID: https://orcid.org/0000-0001-9080-9185)
- Chong Ma (ORCID: https://orcid.org/0000-0002-5054-9259)
- Xiaoshuang Liu
- Ruiying Qin
- Pengcheng Wei (ORCID: https://orcid.org/0009-0006-2955-4324)
- Rongfang Xu
- Huanhuan Wang
- Juan Li
- Ruohan Zhou
- Qing Wang
Institutions
- Anhui Agricultural University (CN)
- Anhui Academy of Agricultural Sciences (CN)
- Wuxi Institute of Technology (CN)
Publication Details
- Journal
- Journal of Integrative Plant Biology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1111/jipb.70177
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Academy of Agricultural Sciences