CD4 <sup>+</sup> T cells facilitate the RT-induced abscopal effect by promoting antigen cross-presentation to CD8 <sup>+</sup> T cells at unirradiated tumor sites
These results demonstrate that an RT-based combination therapy that robustly induces CD4<sup>+</sup> T cells alongside CD8<sup>+</sup> T cells can elicit a strong abscopal response and suggest that CD4<sup>+</sup> effector T cells act at abscopal sites by promoting DC-mediated cross-presentation of tumor antigens to CD8<sup>+</sup> T cells originating from the irradiated tumor.
Authors
- Yizhou Yang (ORCID: https://orcid.org/0000-0002-6411-1178)
- Kateryna Onyshchenko (ORCID: https://orcid.org/0000-0002-9692-1861)
- Liqun Wang (ORCID: https://orcid.org/0000-0002-5714-8001)
- Xi Rao (ORCID: https://orcid.org/0000-0002-8194-9052)
- Meidan Wang (ORCID: https://orcid.org/0009-0000-6524-8881)
- Simone Gaedicke (ORCID: https://orcid.org/0000-0001-7496-4994)
- Elke Firat (ORCID: https://orcid.org/0000-0002-5959-4523)
- G. Niedermann
- Prof Anca-Ligia Grosu
- Siegmar Kuhn
- Ren Luo
- Xuanwei Zhang
Institutions
- Emory University (US)
- Harbin Medical University (CN)
- University of Freiburg (DE)
- Sichuan University (CN)
- University Medical Center Freiburg (DE)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1136/jitc-2025-013055
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00