BACH2 alleviates immune checkpoint inhibitors‐induced cardiac pyroptosis via transcriptionally promoting GRSF1
Immune checkpoint inhibitors cause elevated cardiac injuries in humans and mice ICIs cause myocyte pyroptosis and cardiotoxicity not via the adaptive immune system BACH2 ameliorates ICIs-induced pyroptosis through transcriptionally promoting GRSF1. Lipoic acid as a transcriptional inducer of BACH2 suppresses ICIs-induced cardiotoxicity.
Authors
- Y. L. Wang (ORCID: https://orcid.org/0000-0003-4052-7475)
- Xinjie He (ORCID: https://orcid.org/0000-0002-1810-4209)
- Di Zhao (ORCID: https://orcid.org/0000-0001-6253-7127)
- Wenhao Wang (ORCID: https://orcid.org/0000-0002-0971-4232)
- Mengying Cao (ORCID: https://orcid.org/0000-0003-0276-2298)
- Zilong Liu
- Pan Gao
- Cheng Yang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Henan University Huaihe Hospital and Huaihe Clinical Institute (CN)
- Zhongshan Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/ctm2.70618
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00