Efficacy and safety of the interleukin-10–fragment F8 fusion protein PF-06687234 as add-on therapy to infliximab in patients with active ulcerative colitis: a randomized, phase IIa clinical trial

Efficacy, safety, and tolerability of PF-06687234 as add-on therapy to infliximab in active UC subjects not in remission. https://clinicaltrials.gov/study/NCT03269695. NCT03269695.

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Publication Details

Journal
Therapeutic Advances in Gastroenterology
Published
2026-02-01
DOI
https://doi.org/10.1177/17562848251410784
Primary Topic
Inflammatory Bowel Disease
Type
article
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article

Efficacy and safety of the interleukin-10–fragment F8 fusion protein PF-06687234 as add-on therapy to infliximab in patients with active ulcerative colitis: a randomized, phase IIa clinical trial

Dahong Yu, Joe Palandra, Rupert W. Leong, Jeremy D. Gale et al.
Therapeutic Advances in Gastroenterology
Inflammatory Bowel Disease
article

Efficacy and safety of the interleukin-10–fragment F8 fusion protein PF-06687234 as add-on therapy to infliximab in patients with active ulcerative colitis: a randomized, phase IIa clinical trial

Dahong Yu, Joe Palandra, Rupert W. Leong, Jeremy D. Gale, Dean Messing, Christopher Tehlirian, Vivek Pradhan, Ravi Shankar P. Singh, Silvio Danese, Séverine Vermeire, Stefan Schreiber
article en

Abstract

Efficacy, safety, and tolerability of PF-06687234 as add-on therapy to infliximab in active UC subjects not in remission. https://clinicaltrials.gov/study/NCT03269695. NCT03269695.

Therapeutic Advances in GastroenterologyVol. 19
The University of Sydney (AU), Pfizer (United States) (US), Concord Repatriation General Hospital (AU), University Hospital Schleswig-Holstein (DE), IRCCS Ospedale San Raffaele (IT), University of Lübeck (DE), Macquarie University (AU), KU Leuven (BE)
Good health and well-being
Openalex Percentile: Top 57%
Inflammatory Bowel Disease
DOIOpen Access PDFOpenAlex
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