Intentions and attitudes of caregivers towards enrolment of their children and adolescents living with HIV into remission trials involving analytic treatment interruption
Across multiple countries, guardians of children and youth who were treated early were positive about participation in trials with ATI. Only a third expressed some concern about trial burden, while almost half had unrealistic expectations about potential benefits. Recruitment into trials involving ATI will need to include effective communication strategies to ensure that participants and caregivers are adequately informed about burden, potential risks and the likelihood of personal benefit.
Authors
- K. Reddy
- S. Pahwa
- M F Cotton
- Maria Grazia Lain (ORCID: https://orcid.org/0000-0002-4748-2794)
- Paolo Dalla Palma (ORCID: https://orcid.org/0000-0001-5939-3003)
- Holly L Peay
- Louise Kuhn
- Avy Violari
- Shaun Barnabas
- Moherndran Archary
- Thidarat Jupimai
- Almoustapha‐Issiaka Maiga
- Tacilta Nhampossa
- Ana Barrios‐Tascon
- Mathias Lichterfeld
- Kennedy Otwombe
- Diana Rutebarika
Institutions
- University of Miami (US)
- Chulalongkorn University (TH)
- RTI International (US)
- Stellenbosch University (ZA)
- Chris Hani Baragwanath Hospital (ZA)
- Great Ormond Street Hospital (GB)
- Ragon Institute of MGH, MIT and Harvard (US)
- Tygerberg Hospital (ZA)
- Fundação Ariel Glaser Contra o SIDA Pediátrico (MZ)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- Manhiça Health Research Centre (MZ)
- Bambino Gesù Children's Hospital (IT)
- Africa Health Research Institute (ZA)
- Joint Clinical Research Centre (UG)
- Walker (United States) (US)
- University College London (GB)
- Columbia University (US)
Publication Details
- Journal
- Journal of the International AIDS Society
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/jia2.70084
- Primary Topic
- Ethics in Clinical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ViiV Healthcare