Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury
This study reveals a novel H₂S-HSPA8-HIF1α-BNIP3 axis in regulating ferroptosis and myocardial injury during sepsis. Protein sulfhydration mediates the cardioprotective effects of H₂S, and Allicin emerges as a promising therapeutic agent for septic cardiomyopathy.
Authors
- Sheng Zhang (ORCID: https://orcid.org/0000-0003-0268-8593)
- Li Zhang (ORCID: https://orcid.org/0000-0001-8780-1043)
- Wang Changnan
- Liu Weina
- Du Jiankui
- Wang Li
- Xiao Jian
- Wang Miao
Institutions
- Shanghai University (CN)
- Shanghai Jiao Tong University (CN)
- United States Department of the Navy (US)
- Shanghai Changzheng Hospital (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1080/13510002.2026.2626159
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00